Posted by: Pdfprep
Post Date: March 4, 2021
A 48-year-old woman presented with a 2-year history of weight gain, easy bruising and mood disturbance.
Investigations:
fasting plasma glucose6.9 mmol/L (3.0C6.0)
low-dose dexamethasone suppression test (2 mg/day for 48 h):
serum cortisol200 nmol/L (<50)
24-h urinary free cortisol (?3)670, 400 and 300 nmol (55C250)
plasma adrenocorticotropic hormone (09.00 h)25.0 pmol/L (3.3C15.4)
MR scan of pituitarynormal
What test is most likely to give a definitive diagnosis?
A . corticotropin-releasing hormone test
B . CT scan of chest
C . high-dose dexamethasone suppression text (8 mg/day for 48 h)
D . octreotide scan
E . petrosal sinus sampling
Answer: E
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